Directions from Pittsburgh

Take 79S to Morgantown
Get on 68 East toward Cumberland MD
Take 1st exit in MD (Friendsville #4)
Take 42 until it merges with 219S

(For people in the South Hills it may be quicker to take 51 into Uniontown and take 40 East to 281 then to 42. This can be little tricky, but once you know the way it can cut out some of the distance)

Directions from DC

Take 270 to 70 West
Get on I-68 West
Follow 68 to Exit 14 - 219S
Follow 219S to Deep Creek Lake

Directions from Baltimore

Take 70 West
Get on I-68 West
Follow 68 to Exit 14 - 219S
Follow 219S to Deep Creek Lake